Molecular genetic techniques for gains and losses of genomic material in a case of acute myeloid leukemia
نویسندگان
چکیده
A 67-year-old male presented with a four-week history of weakness. The complete blood count showed: hemoglobin: 5.1 g/dL, leukocytes 182.55 × 103/ L (23% blasts and 34% monocytes) and platelets: 31 × 109/L. A bone marrow aspirate showed 50.4% of myeloid myeloperoxidase (MPO)-blast cells and 42.4% of dysplastic granulocytic-monocytic series, with alpha-naphthyl acetate esterase positivity in 30% of total nucleated cells. Flow cytometry identified two distinct aberrant blasts (CD4-CD7-CD11c-CD13-CD34-CD117-HLA-DRcMPO+) and myeloid/monocytic (CD14-CD33-CD35-HLA-DRCD11b+) populations. Karyotyping showed monosomy 7 and additional material in the long arm of chromosome 2
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عنوان ژورنال:
دوره 39 شماره
صفحات -
تاریخ انتشار 2017